Who I Am
My Experience
I have worked in biological life sciences for over 20 years. I completed a BSc in Bio-Veterinary Medicine and a PhD in Pharmacology in the United States. I was awarded a prestigious post-doctoral fellowship at the University of Edinburgh, followed by an appointment at the University of Melbourne as a research fellow. I have worked in the United States, the United Kingdom and Australia and I am an expert in the subtleties of the English language in both American and British styles.
Publications: Research Articles
- Kalitsis P, Zhang T, Kim JH, Nielsen CF, Marshall KM, Hudson DF. (2019) Knocking in multifunctional gene tags into SMC complex subunits using gene editing. Methods Mol Biol. 2004:91-102. doi: 10.1007/978-1-4939-9520-2_8.
- Laval M, Dumesny C, Eutick M, Baldwin GS, Marshall KM. (2018) Oral trivalent bismuth ions decrease, and trivalent indium or ruthenium ions increase, intestinal tumor burden in ApcΔ14/+ mice. Metallomics. 10(1): 194-200. doi: 10.1039/c7mt00272f.
- Laval M, Marshall KM, Sachinidis J, Scott A, Eutick M, Baldwin GS. (2017) Complexes of gastrin with In3+, Ru3+ or Ga3+ ions are not recognised by the cholecystokinin 2 receptor. J Biol Inorg Chem. 22(7): 999-1006. doi: 10.1007/s00775-017-1478-8.
- Marshall KM, Laval M, Sims I, Shulkes A, Baldwin GS. (2015) Retro-inverso forms of gastrin5-12 are as biologically active as glycine-extended gastrin in vitro but not in vivo. Peptides. 74:16-22. doi: 10.1016/j.peptides.2015.09.012.
- Marshall KM, Laval M, Estacio O, Hudson DF, Kalitsis P, Shulkes A, Baldwin GS, Patel O. (2015) Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo. Metallomics. 7(10):1390-8. doi: 10.1039/c5mt00147a.
- Laval M, Baldwin GS, Shulkes A, Marshall KM. (2015) Increased gastrin gene expression provides a physiological advantage to mice under hypoxic conditions. Am J Physiol Gastrointest Liver Physiol. 308(2): G76-84. doi: 10.1152/ajpgi.00344.2014.
- Marshall KM, Patel O, Bramante G, Laval M, Yim M, Baldwin GS, Shulkes A. (2013) The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo. Peptides. 46: 83-93. doi: 10.1016/j.peptides.2013.05.009.
- Logie JJ, Ali S, Marshall KM, Heck MM, Walker BR, Hadoke PW. (2010) Glucocorticoid-mediated inhibition of angiogenic changes in human endothelial cells is not caused by reductions in cell proliferation or migration. PLoS One. 5(12): e14476. doi: 10.1371/journal.pone.0014476.
- Patel O, Marshall KM, Bramante G, Baldwin GS, Shulkes A. (2010) The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway. Regul Pept. 165(2-3): 224-31. doi: 10.1016/j.regpep.2010.08.005.
- Cobbe N, Marshall KM, Gururaja Rao S, Chang CW, Di Cara F, Duca E, Vass S, Kassan A, Heck MM. (2009) The conserved metalloprotease invadolysin localizes to the surface of lipid droplets. J Cell Sci. 122(Pt 18): 3414-23. doi: 10.1242/jcs.044610.
- Marshall KM, Andjelic CD, Tasdemir D, Concepción GP, Ireland CM, Barrows LR. (2009) Deoxyamphimedine, a pyridoacridine alkaloid, damages DNA via the production of reactive oxygen species. Mar Drugs. 7(2): 196-209. doi: 10.3390/md7020196.
- Pond CD, Marshall KM, Barrows LR. (2006) Identification of a small topoisomerase I-binding peptide that has synergistic antitumor activity with 9-aminocamptothecin. Mol Cancer Ther. 5(3): 739-45.
- Marshall KM, Holden JA, Koller A, Kashman Y, Copp BR, Barrows LR. (2004) AK37: the first pyridoacridine described capable of stabilizing the topoisomerase I cleavable complex. Anticancer Drugs. 15(9): 907-13.
- Antunes EM, Beukes DR, Kelly M, Samaai T, Barrows LR, Marshall KM, Sincich C, Davies-Coleman MT. (2004) Cytotoxic pyrroloiminoquinones from four new species of South African latrunculid sponges. J Nat Prod. 67(8): 1268-76.
- Marshall KM, Matsumoto SS, Holden JA, Concepción GP, Tasdemir D, Ireland CM, Barrows LR. (2003) The anti-neoplastic and novel topoisomerase II-mediated cytotoxicity of neoamphimedine, a marine pyridoacridine. Biochem Pharmacol. 66(3): 447-58.
- Tasdemir D, Marshall KM, Mangalindan GC, Concepción GP, Barrows LR, Harper MK, Ireland CM. (2001) Deoxyamphimedine, a new pyridoacridine alkaloid from two tropical Xestospongia sponges. J Org Chem. 66(9): 3246-8.
Publications: Reviews
- Kalitsis P, Zhang T, Marshall KM, Nielsen CF, Hudson DF. (2017) Condensin, master organizer of the genome. Chromosome Res. 25(1): 61-76. doi: 10.1007/s10577-017-9553-0.
- Hudson DF, Marshall KM, Earnshaw WC. (2009) Condensin: Architect of mitotic chromosomes. Chromosome Res. 17(2): 131-44. doi: 10.1007/s10577-008-9009-7.
- Marshall KM, Barrows LR. (2004) Biological activities of pyridoacridines. Nat Prod Rep. 21(6):731-51. Epub 2004 Oct 29.
Other Experience
- Presenting at departmental, national and international levels
- Preparing lectures for Xenobiotic Metabolism, Cancer Pathophysiology and Pharmacology courses
- Writing and editing other presentations and NHMRC grant applications